Lab News
September 2025
Anna's paper on heterozygous Med 13L mice craniofacial anomalies is published.
Leinheiser AK, Nguyen TT, Henry KM, Rosales M, Van Otterloo E, Grueter CE. Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome. Developmental Dynamics. 2025;1‐12. Doi:10.1002/dvdy.7007912
Kayla's paper on Med 13/13L redundancy in cardiomyocytes is published.
Henry, KM., Gardner, RN., Oppman, AM., Daneshgar, N., Rosales, M., Martins, I., Baskin, KK., & Grueter, CE. (2025). Med13 and Med13L: Critical redundant players in basal cardiac function and gene expression. Journal of Molecular and Cellular Cardiology Plus, 13, 100481. https://doi.org/10.1016/j.jmccpl.2025.100481
July 2025
Kayla and Connor are appointed to the Genetics T32 Training Grant for the 2025-26 academic year.
Chad and Anna are invited to speak at the Med13L Family Research Day Conference.
June 2025
Kayla wins 1st place for her poster at the 50th Anniversary Genetics Student Retreat.
Anna and Kayla receive a travel grant from Uplifting Athletes.
May 2025
Ismail Ademi, medical student, joins the Grueter Lab.
Kayla passes her comprehensive exam.
Anna is invited to give a talk as a Marie Currie Speaker at College of Saint Mary.
Chad is named associate editor to the Journal of the American Heart Association.
Chad gave an invited talk titled "Models of MED13L Syndrome" to the Asociación afectados MED13L espana.
February 2025
Ella Riniker, an undergraduate student, joins the Grueter Lab.
November 2024
Kayla wins first place for Best Trainee Presentation at the 50th Anniversary ACRC Symposium.
Anna wins first place for Best Postdoctoral Poster at the 50th Anniversary ACRC Symposium: A dynamical systems model for the total fission rate in DRP1 dependent mitochondrial fission.
Anna's paper on DRP1- dependent mitochondrial fission is published.
A Dynamical System Model for the Total Fission Rate in DRP1-Dependent Mitochondrial Fission
Leinheiser AK, Mitchell CC, Rooke E, Strack S, Grueter CE. A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission. PLoS Comput Biol. 2024 Nov 18;20(11):e1012596. doi: 10.1371/journal.pcbi.1012596. PMID: 39556606; PMCID: PMC11611272.
August 2024
Connor Kirk, a genetics PHD student, joins the Grueter Lab.
Connor is awarded the Iowa Recruitment Fellowship from the Graduate College.
July 2024
Chad is awarded an NIH R01 for "Mediator kinase regulation of cardiac transcription."
Kayla is appointed to the Genetics T32 Training Grant for the 2024-25 academic year.
Anna is appointed to the Diabetes T32 Training Grant for the 2024-25 academic year.
Nastaran successfully defends her thesis titled "Klotho-Sirt1-CHK2 Pathways in the Regulation of Cardiac Function in Aging and Post-Myocardial Injury."
May 2024
Christopher Jun, medical student, joins the Grueter Lab.
Mariela Rosales, un undergraduate student, joins the Grueter Lab.
October 2023
Chad was an invited speaker at the Rowan-Virtual School of Osteopathic Medicine.
Nastaran receives the 2024 spring Graduate College Post-Comprehensive Research Fellowship.
August 2023
Dr. Anna Leinheiser joins the Grueter Lab.
Kayla Henry, a genetics PHD student, joins the Grueter Lab.
May 2023
Chad receives the MED13L Foundation Pilot Award for the project "Physiological and molecular signatures in mouse models of MED13L Syndrome."
August 2022
Chad gave an invited talk titled "Mouse models of MED13L and associated genes" to Simons Searchlight.
July 2022
Chad receives the American Heart Association Transformative Program Award for "Mediator kinase regulation of cardiac hypertrophy."
May 2021
Chad is awarded an NIH R03 for "Cdk-19-dependent transcriptional mechanisms in cardiac hypertrophy."
Eva's paper on mitral valve disease is published.
Mining Metabolomics in Mitral Valve Disease
Scheibe EL, Grueter CE. Mining Metabolomics in Mitral Valve Disease. J Am Heart Assoc. 2021 May 4;10(9):e020726. doi: 10.1161/JAHA.121.020726. Epub 2021 Apr 23. PMID: 33890481; PMCID: PMC8200764.
April 2020
Jessica's paper on Cyclin C and mitochondrial dynamics is published.
Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics
Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A Jr, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. J Am Heart Assoc. 2020 Apr 7;9(7):e014366. doi: 10.1161/JAHA.119.014366. Epub 2020 Apr 4. PMID: 32248761; PMCID: PMC7428645.
September 2019
Rachel's paper on gene expression is published.
Targeting Transcriptional Machinery to Inhibit Enhancer-Driven Gene Expression in Heart Failure
Minerath RA, Hall DD, Grueter CE. Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure. Heart Fail Rev. 2019 Sep;24(5):725-741. doi: 10.1007/s10741-019-09792-3. PMID: 30972522; PMCID: PMC6698214.
July 2019
Jessica successfully defends her thesis titled "Investigating the roles of Cyclin C in heart disease."
May 2019
Rachel successfully defends her thesis titled "Mediator kinase submodule-dependent regulation of cardiac transcription."
April 2019
Rachel's paper on Med 13 is published.
Regulation of Cardiac Transcription by thyroid Hormone and Med 13
Minerath RA, Dewey CM, Hall DD, Grueter CE. Regulation of cardiac transcription by thyroid hormone and Med13. J Mol Cell Cardiol. 2019 Apr;129:27-38. doi: 10.1016/j.yjmcc.2019.01.007. Epub 2019 Feb 12. PMID: 30769017; PMCID: PMC6510257.
February 2019
Duane's paper on Med1 and RNA Polymerase II is published.
Hall DD, Spitler KM, Grueter CE. Disruption of cardiac Med1 inhibits RNA polymerase II promoter occupancy and promotes chromatin remodeling. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H314-H325. doi: 10.1152/ajpheart.00580.2018. Epub 2018 Nov 21. PMID: 30461303; PMCID: PMC6397381.
September 2018
Chad receives a Pilot Grant from FOEDRC to study nuclear regulation of mitochondria.
August 2018
Chad was invited to speak at Mini medical school.
July 2018
Chad receives a Carver Trust Pilot Grant for the project "Targeting Cyclin C dependent regulation of cardiac transcription and metabolism in ischemic heart disease."
March 2018
Jessica is awarded an NIH F31 for her project "Dual Roles of Cyclin C in Heart Disease."
October 2017
Rachel wins 3rd Place for the Best Trainee Poster Presentation at University of Iowa Department of Internal Medicine Research Day
Her Poster was :"CDK8 activity-dependent regulation of heart disease"
September 2017
Colleen wins Postdoctoral category of the ‘A Minute to Win It’ Poster Competition during the 22nd Annual Meeting of the Iowa Physiological Society.
August 2017
Duane's paper on CDK8 in the heart is published.
Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure.
Hall DD, Ponce JM, Chen B, Spitler KM, Alexia A, Oudit GY, Song LS, Grueter CE. JCI Insight. 2017 Aug 3;2(15). pii: 92476. doi: 10.1172/jci.insight.92476.
Read more at The Scientist
July 2017
Katie wins 2nd place in the Papajohn Biomedical Institute best paper competition for her paper: Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.
April 2017
Katie wins Travel award from ScienceImpact to attend Experimental Biology 2017
Colleen is invited to give a talk at the FOEDRC Research Day
She presents "Med12 is an essential, early regulator of adipogenesis"
February 2017
Katie's paper on Med1 is published
Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.
Spitler KM, Ponce JM, Oudit GY, Hall DD, Grueter CE. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H768-H780. doi: 10.1152/ajpheart.00728.2016. Epub 2017 Feb 3.
October 2016
Chad gave an invited talk titled "MED1 is necessary for cardiac transcriptional regulation of oxidative metabolism" at the Society for Heart and Vascular Metabolism meeting.
July 2016
Jessica wins 1st Place for the Best Trainee Poster Presentation at University of Iowa Department of Internal Medicine Research Day
Her Poster was :"Dual Roles of Cyclin C in Cardiovascular Disease"
November 2015
Chad was an invited speaker at the American Heart Association Scientific Sessions.
Chad gave an invited talk over "The heart's ability to regulate systemic metabolism" at the Fraternal Order of Eagles Winter meeting.
Colleen's review of secreted factors as biomarkers is published
Cardiac-Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers.
Dewey CM, Spitler KM, Ponce JM, Hall DD, Grueter CE. J Am Heart Assoc. 2016 May 31;5(6). pii: e003101. doi: 10.1161/JAHA.115.003101. No abstract available.
September 2015
Chad was an invited speaker at the Annual Meeting of the International Academy of Cardiovascular Sciences: North American Section.
Jessica is awarded the Sloan Center Mini Grant.
January 2015
Jessica Ponce joins the lab as a graduate student.
Jessica plans to study the role of Cyclin C in the cardiovascular system.
November 2014
Chad is awarded an NIH R01 for "MED13 regulation of cardiac transcriptional reprogramming in obesity and hypothyroidism."
September 2014
Dr. Colleen Dewey joins the lab as a postdoctoral fellow.
Colleen intends to investigate the involvement of the Mediator complex in metabolic disease.
June 2014
Ines Martin joins the lab.
Ines will focus on cardiovascular surgeries to provide critical models of stress for the lab.
April 2014
Funding awarded to Dr. Katie Spitler, NIH T32 Postdoctoral Fellowship.
Title: MED 13 regulates cardiac energetics in response to obesity.
March 2014
Dr. Katie Spitler joins the lab as a postdoctoral fellow.
Katie’s research will encompass MED13 and MED1 and there role in cardiac function.
January 2014
New graduate student, Rachael Minerath, has joined the lab.
Rachael’s work will be focused on the function of CDK19 in the heart under normal and stress conditions.
December 2013
Dr. Duane Hall joins the label as a research professor.
Duane intends to focus his efforts on eliciting the role of CDK8 in cardiac function.
January 2013
Dr. Chad Grueter starts the lab at the University of Iowa – Department of Internal Medicine.